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KMID : 0606320040210010093
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Journal of Phamacetical Sciences Sookmyung Women s University
2004 Volume.21 No. 1 p.93 ~ p.97
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The effect of Petasites japonica on CCl4 induced hepatotoxicity
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Yang Ki-Sook
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Abstract
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Petasites japonicus(Compositae) is a perennial herb which has been used as analgesic, antitussive, expectorant, sedative in folk remedies. We examined anti-lipid peroxidative and liver protective effects of MeOH extract of it on CCl4 induced lipid peroxidation and hepatotoxicity in rats. The anti-lipid peroxidation activity of them showed by dose dependently and especially, administration group 2.0 g/kg was recovered as normal group. Serum transaminase, GOT, GPT and AIP activities increased by carbontetrachloride were significantly decreased by administration of MeOH extract. From the above results, it can be summerized that Petasites japonicus has anti-lipid peroxidative and liver protective effects.
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